This lab develops new biomedical materials (scaffolds, implants, etc.) that have cutting edge capabilities in effectively reconstructing or regenerating damaged human tissues. In particular, research is being conducted into developing state-of-the-art biomedical printing technology that can manufacture intelligent scaffolds and implants that have patient-tailored, three-dimensional structures and biological functions. In addition, the lab is engaged in research into the development of a new multiscale, bio-inspired material that can closely imitate human tissue on the macro, micro, and nano scales, and into the development of various surface processing technologies that can innovatively improve the functionality of implants.
The Bio-optics lab conducts research related to the application of optics for the development of medical imaging and application equipment. Imaging the functionality of human tissue or cells in high resolution establishes the foundation for medical diagnosis and basic science research. We are also at the forefront of optics-related instrument development through joint research projects with domestic and foreign companies, hospitals, and research institutes focused on the newest optics and optical technology.
Major Research Fields
Optical coherence tomography
Near-infrared spectroscopy
Two photon microscopy
Fluorescence imaging system
Tweezer
Brain Reverse Engineering by Intelligent Neuroimaging Laboratory
For the diagnosis and analysis of brain disease, the lab's computational method uses structural magnetic resonance imaging, functional magnetic resonance imaging, and tensor diffusion. Based on the characteristic of each image, curvature base analysis, structural analysis, and network analysis are performed.
Major Research Fields
Cortical Sulci and folding patterns analysis
Spectral-based shape analysis
Diffusion tensor image (DTI) analysis
Brain network analysis based on DTI
Dimension reduction based on high-dimentional space
Group analysis between normal control and dementia
Medical imaging allows non-invasive image acquisition of a target's interior to provide information necessary for diagnosing diseases. Molecular imaging is an emerging field of medical imaging which can elucidate and quantify cellular or subcellular characteristics with nuclear medicine being the representative modality used in the clinic. At the Molecular Imaging Systems Laboratory, the focus is on developing instrumentation, such as detectors and electronics, to improve the performance of existing equipment.
Major Research Fields
Design, simulation and development of radiation detectors and systems for medical and non-medical applications such as x-ray, PET (Positron Emission Tomography) and homeland security
Design and development of front-end electronics, including ASIC (application specific integrated circuits).
Development of medical radiation imaging systems.
Research and development of radiation probes for fields such as nuclear medicine.
Research into multi-modality medical imaging systems (PET-MR, PET-Optic, etc.).
Exploration of innovative medical imaging techniques.
Nano-Biosystem Lab is a specialized laboratory that investigates a variety of biological phenomena and disease-related mechanisms existing in nature at the molecular or nano scale. To achieve this goal, nanotechnology-based multi-disciplinary approach is adopted to carry out various types of researches that need to process nanoscale analyses. Research interest of our lab includes biosensors for diagnosing lethal diseases, drug delivery systems for cancers or diabetes, drug screening systems for seeking optimal drug of Alzheimer’s disease, and atomic force microscopy studies for disentangling the secrets of interactions between various biomolecules.
Major Research Fields
Atomic force microscopy studies for disentangling interaction between disease-related biomolecules.
Development of various types of biosensors for diagnosing lethal diseases.
Development of nanoparticle-based drug delivery system suitable for practical use in the body.
Synthesis of various biomaterials and their biomedical applications.
Development of drug screening system for Alzheimer’s disease.
By using the various physical principles related to radiation, electrical and magnetic fields, and heat, the lab carries out research aimed at developing state-of-the-art cancer treatment technologies.
In the radiation cancer treatment field, the lab strives to develop software and hardware that can verify in real time the radiation ray quantity and distribution during radiation treatment, and to develop an external monitoring system for radiation treatment instruments. The use of electrical fields in cancer treatment is a newly acclaimed cancer treatment technology, because it has fewer side effects compared to existing cancer treatments.
This lab investigates the physical and biological mechanisms of electrical field cancer treatment, and through the development of an electrical field planning system and an electrical field generator device, it conducts research aimed at making it one of the four major cancer treatments along with surgery, chemotherapy, and radiation treatment.
Major Research Fields
Analysis of secondary cancer occurrence probability during patient treatment.
Development of proton measurement device that uses Cerenkov radiation.
Development of real time patient ray quantity monitoring system that focuses on transmission dosage.
Development of cancer treatment technology using electrical fields.
Development of radiation treatment instrument external monitoring system.
Nano/bio Interface Lab.
Lee, Kyu-Back
Office : Hana Science Hall B 463
Laboratory Introduction
This lab is conducting convergence research into Nanostructure production (Materials) and the signal transmission mechanism (Life Sciences) within the cells in the Nanostructure. These categories of research are separate lines of inquiry, and the research and idea generation process benefits from communication between the two strands of research. Work is centered around the manufacturing of Nano structures that have various dimensions and functionality, and the analysis of cell movement change when external stimulation is applied.
Major Research Fields
Nanostructure manufacturing using Alumina.
Nanostructure manufacturing using Nano particles.
Development of two-dimensional gradient board using Nanostructure and functional proteins.
Exploration of conditions for maintenance of stem cell’s functionality.
Analysis of protein and cytokine to investigate signal transmission within cells.
Nanoneedle fabrication and applications for intracellular delivery of substances.
The Medical Information Processing Laboratory (MIPL) focuses on medical imaging diagnostic instruments that provide useful information to enable better diagnosis of diseases. The lab conducts innovative research into hardware and software technologies needed in the medical imaging field such as the development of semiconductor-based high-resolution gamma ray imaging detectors and high performance 3D image reconstruction algorithms. Furthermore, the know-how attained from the medical imaging field are transferred to research into safety and industrial equipment such as disaster monitoring and non-destructive examination systems.
Major Research Fields
High resolution SPECT using Variable Pinhole Collimator
Positioning Algorithm for CZT Virtual Frisch-grid Detector
Multi-purpose Super-resolution Gamma Detector
High Energy Collimator Design for I-131
Multi-pinhole SPECT
Image Registration for Breast Cancer Study
Plasma-Display-Panel based X-ray Detector (PXD)
Patient Dose Analysis and Image Quality Assessment in CT Fluoroscopy
Image Quality Evaluation for OSEM(DB) Reconstruction
Treatment of disease starts with accurate diagnosis, and good analytic instruments are the foundation of research activity. Through the development of simple and accurate diagnostic instruments and technology, the Experts Group is striving to develop technologies that will form a ‘global health application’, especially for the purpose of contributing to third world disease prevention. Research is also being done to develop technology that will dramatically reduce the time and costs required for new drug development. Research into high-resolution neuro-interface that can interrogate single axon activity is also being conducted.
Major Research Fields
High-resolution neuro-interface
DNA synthesis
Exosome separation & analysis
Micro/nanofluidics
Point-of-care diagnostics
Medical instrument
Biomicrofluidics Laboratory
Chung, Aram
Office : Hana Science Hall B 270
Lab: Hana Science Hall B 255
The Biomicrofluidics Laboratory is a research group devoted to research on investigating low Reynolds number microscale flows. Based on a series of fundamental studies of inertial fluid behaviors in microscale and its integration with other modalities, the lab is developing a new class of practical high-throughput microfluidic systems for biology and medicine.
Major Research Fields
- Cell deformability based cancer and disease diagnosis
The NanoBioPhotonics Lab is conducting research that is broad in scope thanks to its focus on the convergence of Nano, biological, and optical technologies. Currently, research is being conducted into surface plasmon phenomenon-based proton extraction, Nanostructure manufacturing for disease diagnosis, and Nano technology-based dedifferentiation stem cell manufacturing. In addition, technologies that will establish a new paradigm in the Nano/bio technology and basic science fields are being developed.
Major Research Fields
Develop cancer diagnosis technology using exosome detection based on Surface-enhanced Raman scattering method.
Develop plasmon resonance energy transfer effect technology for intravital pH extraction.
Manufacture Nanostructures compatible with medical instruments.
Manufacture stem cells through quantitative injection of dedifferentiation factor within cells.
Biophotonics Imaging Laboratory
Choi, Youngwoon
Hana Science Hall B 268
Laboratory Introduction
Optical microscopy has been one of the major imaging methods for biological and medical areas due to its superior resolution and nontoxicity for most biological samples. However, shallow imaging depth and no specificity for chemical compounds are often obstacles that limit its applications to broad research and clinical fields. In order to overcome the limitations in optical imging, the Biophotonics Imaging Lab is developing new microscopic techniques based on physics principles to add enhanced performances and new functions to existing imaging methods.
Our lab is mainly focusing on the development of ultra-thin and high-resolution endomicroscopes using digital holographic imaging techniques, highly sensitive phase microscopes for measuring nanometer-scale cellular dynamics, and deep-tissue imaging methods based on the state-of-the-art wavefront control technology. For clinical purposes, we are also developing highly efficient probes for photothermal therapy with no cutaneous thermal damages and diagnostic protocols for cancerous disease based on the polarization measurements.
Major Research Fields
Development of ultra-thin and high-resolution endomicroscopes.
Development of nm-scale-sensitive phase microscopes.
Polarization sensitive measurement for 2D/3D imaging.
Measurement of cellular dynamics for disease diagnosis.
High depth imaging methods based on wavefront manipulation techniques.
